Molecular Characterization of CYP2B6 Substrates
نویسندگان
چکیده
منابع مشابه
Characterization of SiO2-TiO2 Coatings on 316l Stainless Steel Substrates
This paper reports nano-structured SiO2-TiO2 coatings using the sol-gel technique on 316L steel substrates. Nanoindentation, surface analysis and corrosion resistance tests were performed on different samples. The nanomechanical tests allowed to compare uncoated steel samples (Eavg = 193.24 GPa and mean hardness of 2.63 GPa and coated steel samples (Eavg = 287.38 GPa and mean hardness of 5.74 G...
متن کاملRegioselectivity of CYP2B6: homology modeling, molecular dynamics simulation, docking.
Human cytochrome P450 (CYP) 2B6 activates the anticancer prodrug cyclophosphamide (CPA) by 4-hydroxylation. In contrast, the same enzyme catalyzes N-deethylation of a structural isomer, the prodrug ifosfamide (IFA), thus causing severe adverse drug effects. To model the molecular interactions leading to a switch in regioselectivity, the structure of CYP2B6 was modeled based on the structure of ...
متن کاملThree-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6.
To begin to build an understanding of the interactions of CYP2B6 with substrates, two different 3-dimensional quantitative structure activity relationship (3D-QSAR) models were constructed using 16 substrates of B-lymphoblastoid expressed CYP2B6. A pharmacophore model was built using the program Catalyst, which was compared with a partial least-squares (PLS) model using molecular surface-weight...
متن کاملMolecular Characterization of Aureobasidium Species in Iran
Background: Members of this genus Aureobasidium are ubiquitous microorganisms which can be isolated from wide ranges of substrates such as plant materials (phyllosphere, plant debris, bark, roots, fruits and wood), soil, dead wood, air, and as rare etiologic agent of pheohyphomycosis, keratomycosis, septicemia, peritoneal sepsis, and dermatological infections in human. Very little is known on t...
متن کاملsynthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Drug Metabolism
سال: 2008
ISSN: 1389-2002
DOI: 10.2174/138920008784746346